Integrative Aspects of Calcium Signalling

by Alexej Verkhratsky (Editor), Emil C. Toescu (Editor)

Overview

Here is the first effort in a single volume to cover all of the integrative functions of calcium signalling - how changes in intracellular calcium coordinate a variety of coherent cellular responses. Written by a team of internationally established researchers, Integrative Aspects of Calcium Signalling provides the latest experimental data and concepts, bringing together a detailed analysis of the events, processes, and functions regulated by calcium signalling. A unique resource for professionals and students of physiology, biophysics, neurobiology, biochemistry, and all related fields.

Product Details

ISBN-13:	9780306460326
Publisher:	Springer US
Publication date:	10/31/1998
Edition description:	1998
Pages:	408
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

Introduction: Principles of Calcium Signalling.- One: Calcium Regulation of Cellular Systems.- 1. The Fate of Calcium Ions Entering a Cell: Calcium Transport through Organelles.- 2. Calcium Regulation of Cytosolic Enzymes.- 3. Function of Nuclear and Cytoplasmic Calcium in the Control of Gene Expression.- 4. Calcium Regulation of Ion Channels.- 5. Modulation of NMDA Receptor Channels by Intracellular Calcium.- 6. Regulation of InsP3R by Ca2+ and Cytosolic Ca2+ Dynamics.- 7. Regulation of Ca2+-Release Channels by Luminal Ca2+.- 8. Mihondrial Ca2+ Signalling.- 9. Modulation of the Cytoskeletal Architecture by Calcium: A Putative Role in Plastic Synapses.- Two: Calcium Regulation of Cellular Functions.- 10. Calcium and Exocytosis.- 11. Calcium and Neuronal Development and Growth.- 12. Calcium and Cellular Death.- 13. Calcium-Dependent Signalling in Apoptosis.- 14. The Spatial Range of Dendritic Signals for Cerebellar Long-Term Depression: Studies with Local Photolysis of Caged Compounds.- 15. Calcium and Activity-Dependent Synaptic Plasticity.- 16. Ca2+ Waves as a Form of Glial Excitability.- 17. Local Control in Calcium Signalling during Cardiac E-C Coupling.

Editorial Reviews

This book is a series of comprehensive reviews on the roles of calcium in biological phenomena. Topics include discussions of the regulatory role of calcium, effects of calcium on receptors, cell growth, apoptosis, neurotransmission, and cardiac conduction. The purpose is to provide information on the roles of calcium in biological phenomema. The reviews are accompanied by extensive bibliographic citations which provide valuable documentation. As such, this volume will be of interest to investigators in the signal transduction field with a special emphasis on working with calcium. The first chapter on the principles of calcium signaling sets the framework for subsequent sections. These cover the roles of calcium in regulation of gene expression, ion channels, receptors, and as a modulator of enzymatic activities in the cytosol. Material is limited, but this is not a major drawback. The literature coverage is excellent although there are few citations more recent than 1996, a common problem in multi-author volumes. Additional topics include functions of calcium in the mitochondria, effects on the cytoskeleton and secretary functions, as well as development and apoptosis. The breadth of coverage is thorough and as such, has appeal to a broad audience. This book would serve as an effective companion to one focused on the practical aspects of calcium measurement. I would recommend this book.

Eugene A. Davidson

A broad summary of the current status of knowledge now that a reasonably detailed outline of the main players has emerged and it is possible to begin painting an overall picture of cellular calcium regulation. Describes the subtle cytosolic spatiotemporal calcium signal patterns that have been long studied, but also recent attention developments in the direct monitoring of calcium concentration changes in various organelles, which has revealed many unexpected roles calcium plays in integrating cell function. Among the perspectives explored are the fate of calcium ions entering a cell, the function of nuclear and cytoplasmic calcium in controlling gene expression, calcium and exocytosis, and calcium-dependent signaling in apoptosis. Annotation c. by Book News, Inc., Portland, Or.

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