Ezra "Jinx" Helm is as dead as Elvis. But we all know Elvis isn't really dead, and neither is Jinx. At least, he hopes so. A mortar blast took him from the Earthly plane of existence at age twenty-eight, but his sister, Eliza, just happens to come from a long line of healing witches. Him being a warlock doesn't quite pack the punch he needs to keep himself corporeal. Because she loves her brother so, and he owes her five-hundred smackaroos, she is able to heal him and bring him back to the land of the living, temporarily.
Constance Medina Maria Luisa Dulce de Vargas y Aguilar is also dead. She's been groomed to take over as Nuestra Senora de la Santa Muerte, aka Our Lady of the Holy Death, or as she prefers, Lady Death. While she doesn't mind ushering in new souls into the afterlife playground—which looks a lot like a resort in Playa del Carmen—she's being forced to marry one of the Lords of Xibalba to maintain balance in the underworld, and she's not happy about it one bit. In a panic, she runs away from the realm of the dead and ends up in Assjacket, WV. Connie meets a ridiculously powerful and fantastically wardrobed witch named Zelda, who she hopes can get her out of the arranged marriage.
Jinx knows his sister can only keep up the farce of him being undead for so long, as he died in World War II and she's been getting really pissy about having to renew his spell every month. He seeks out the most powerful healing witch he knows for help. But Zelda has her own set of problems with a husband, kids, a forest full of animals needing healing and Lady Death hanging around her doorstep like an emo Eeyore. In exchange for her help, Zelda offers Jinx a deal, take Santa Muerte off her hands for a little bit and she'll figure out a way to bring him back from the dead, permanently.