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Volume V deals with the problems of turnover in the nervous system. "Turnover" is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here "turnover" in­ dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in aseparate chapter dealing with the synthesis ofpr...