Migraine Pain Management: Current Pharmacological and Non-pharmacological Options

by Stephen B. Shrewsbury (Editor)

Overview

Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients. - Offers a comprehensive overview of pharmacological and alternative migraine pain treatment options - Covers the historical developments and current targets for drug development and delivery routes - Provides insights into comorbidities and their impact in patient compliance to treatment

Product Details

ISBN-13:	9780443247040
Publisher:	Elsevier Science & Technology Books
Publication date:	10/24/2024
Sold by:	Barnes & Noble
Format:	eBook
Pages:	500
File size:	62 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Stephen Shrewsbury recently left Impel Pharmaceuticals where he served as Chief Medical Officer (CMO) from March 2017 and led the development of Precision Olfactory Delivery of DHE through its clinical program and to FDA approval in September 2021. Formerly Stephen was CMO at MAP Pharmaceuticals where he conducted a successful clinical program for an inhaled version of DHE, but it never got approved due to manufacturing issues. Before MAP he was at Chiron Corporation where he was also on the International Pharmaceutical Aerosol Consortium Board of Science. Before Chiron, Stephen spent 9 years with GlaxoSmithKline (last 2 in the US) having moved into the industry in 1993 after 13 years working in the UK’s National Health Service. He has also been CMO for several other West Coast (US) biotech companies; has numerous patents; written and published a book, over 40 scientific papers and nearly 200 abstracts

Table of Contents

Part I: Foundations and historical development of migraine pain management 1. Introduction2. Neuroanatomy and Neurophysiology3. Historical overview of migraine product development 4. Comorbidities and their impact on therapies 5. Not all Migraine attacks are the same 6. Challenges and Controversies; Pharmacokinetics, Linguistics, Semantics and Statistics Part II: Druggable targets7. CGRP8. PACAP 9. Src family kinases (SFK) in Migraine10. Delta opioid receptor system 11. Piezo channels in peripheral trigeminal nociception 12. TRP antagonists Part III: Drugs – Acute Management13. Simple analgesics and combination oral products14. Cannabinoids & Phytochemicals15. Ergots 16. Triptans 17. Beta blocker (timolol) eye drops 18. Lasmiditan (and the ditan class) 19. Gepants Part IV: Drugs – Prevention20. TCAs (Tricyclic Antidepresants), SNRIs, Beta blockers, candesartan, flunarizine21. Antiseizure orals (gabapentin, topiramate)22. Onabotulinumtoxin 23. Gepants (for prevention)24. (CGRP) Monocloncal antibodies Part V: Administration routes25. Oral Drugs (including SMEDDS) 26. Inhaled - oral & nasal27. Subcutaneous/IM/Transcutaneous ("Injectables") 28. IV/Infusion Part VI: Alternative Management29. The role of digital platforms and smartphone apps30. Herbal Medicines31. Phototherapy 32. Neuromodulation 33. Acupuncture (for episodic and chronic migraine)34. Manual Therapies 35. Nutraceuticals and Diets 36. Mindfulness Part VII: Summary & conclusion [Shrewsbury]37. Final Perspectives: oral/non-oral pharmaceuticals; devices; Complimentary practices

What People are Saying About This

From the Publisher

A comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects to manage migraine pain

Editorial Reviews

"...offers a thorough overview of the history, pathophysiology, and available treatments for migraine, including both pharmacological and non-pharmacological approaches.... [It] aims to give a thorough understanding of migraine as a disease and the latest advancements in the field of headache medicine,... offers a well-considered framework for those looking to build their foundational understanding of migraine pathophysiology and management,... [and] provides an extensive overview of migraine as a disease.... The writing is well organized, easy to understand, and structured with a logical flow.... written by authoritative figures in the field of headache medicine and contains a comprehensive review of migraine treatment options, book's organization and clarity make it an invaluable resource.... It is an excellent supplement to existing literature and serves as a strong reference for healthcare providers seeking to enhance their understanding of treatment strategies.... recommend[ed] for trainees and practicing clinicians looking to expand their fundamental knowledge on migraine." ©Doody's Review Service, 2025, Suraj Malhan, DO, MS (Thomas Jefferson University)

From the Publisher