Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease

by Gokhan Burcin Kubat (Editor), Oner Ulger (Editor), Serdar Gunaydin (Editor)

Overview

Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types.

Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application.

- Provides an in-depth discussion of mitochondrial transplantation, considering fundamental biology, disease implications, research methods and applications

- Discusses recent advances in the field and their meaning for future research and clinical utility

- Considers ethical dimensions of mitochondrial transplantation research and use in therapeutics

- Examines mitochondrial transplantation across a range of disease types, from neurological to cardiovascular disease and ischemia

Product Details

ISBN-13:	9780443188596
Publisher:	Elsevier Science & Technology Books
Publication date:	08/03/2024
Series:	Translational and Applied Bioenergetics
Sold by:	Barnes & Noble
Format:	eBook
Pages:	430
File size:	25 MB
Note:	This product may take a few minutes to download.

About the Author

Gokhan Burcin Kubat currently serves as a Unit Manager in the Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences, Turkey. He also attended the "Molecular Diagnostic Practicum" training at Virginia Commonwealth University, USA, and worked in the field of molecular pathology. He has contributed to research in mitochondrial transplantation and mitochondrial biogenesis with 10 peer reviewed publications, including in the Journal Molecular Medicine, Mitochondrion, Life Sciences, Biochimie, Journal of Biochemical and Molecular Toxicology, Toxicology and Applied Pharmacology, Cardiovascular Drugs and Therapy and Turk J Sports Med.

Oner Ulger currently serves in the Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences in Ankara, Turkey. He got his doctorate from the Department of Physiology, Health Sciences Institute, University of Health Sciences in Turkey. He studies mitochondrial transplantation with high-impact research and review articles including in published in the Life Sciences, Biochimie, Journal of Biochemical and Molecular Toxicology, Toxicology and Applied Pharmacology, Mitochondrion, and Journal of Molecular Medicine.

Dr Gunaydin currently serves as a faculty and clinical professor in the Department of Cardiovascular Surgery in Ankara City Hospital Campus, University of Health Sciences, Turkey. He studied histology and embryology and received PhD in Biomaterial Sciences in Tokyo Heart Institute, Japan. He is the Vice President for International Society of Minimally Invasive Extracorporeal Circulation (MiECTIS) and General Secretary of Turkish Enhanced recovery After Surgery (ERAS) Society. He also works as the scientific board member in Giganode Foundation and Heart Team Education Association. He directs international scientific projects on clinical evaluation and biomaterial confirmation of novel cardiopulmonary bypass-related technologies based on the prevention of inflammatory response, patient blood management and ERAS.

Table of Contents

Part 1: Introduction1. Mitochondrial Transplantation: Methods and Mitochondrial Dysfunction Diseases: An Overview2. Mitochondria and Cell Metabolism3. Mitochondrial Dynamics and Mitochondrial Biogenesis4. Mitochondrial DNA and HeteroplasmyPart 2: Physiological Mitochondrial Transfer5. Tunnelling Nano Tube (TNT)6. Microvesicles and Gap JunctionsPart 3: Mitochondrial Transplantation from Isolation Process to Application7. Isolation Process for Mitochondrial Transplantation8. Determination of Mitochondrial Number and Function9. Storage of Isolated Mitochondria10. Mitochondrial Transplantation Methods11. Application Route of Mitochondrial Transplantation12. Limitations of Mitochondrial Transplantation13. Ethical Issues about Mitochondrial TransplantationPart 4: Cardiovascular Diseases and Mitochondrial Transplantation14. Cardiovascular Diseases and Pathophysiology15. Pre-clinical Studies16. Clinical StudiesPart 5: Neurological Diseases and Mitochondrial Transplantation17. Neurological Diseases and Pathophysiology18. Pre-clinical StudiesPart 6: Other Diseases and Mitochondrial Transplantation19. Hereditary Mitochondrial Diseases and Mitochondrial Transplantation20. Kidney Injury and Mitochondrial Transplantation21. Cancer and Mitochondrial Transplantation22. Diabetes and Mitochondrial Transplantation24. Aging and Mitochondrial Transplantation25. Future Aspects of Mitochondrial Transplantation

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From the Publisher

An in-depth but accessible treatment of mitochondrial transplantation and transfer, considering fundamental biology, methods, and applications