Modulators, Mediators, and Specifiers in Brain Function: Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders

While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac­ count for the pathogenesis of certain psychiatric ill­ ...