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Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

By Patrick G. Hogan, Richard S. Lewis, Anjana Rao
eBook
$9.99
By Patrick G. Hogan, Richard S. Lewis, Anjana Rao
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Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective channels known as CRAC (calcium release-activated calcium) channels. CRAC channels are a very well-characterized example of store-operated Ca2+ channels, so designated because they open when the endoplasmic reticulum (ER) Ca2+ store becomes depleted. Physiologically, Ca2+ is released from the ER lumen into the cytoplasm when activated receptors couple to phospholipase C and trigger production of the s...

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