Neural Mechanisms of Addiction

by Mary Torregrossa PhD (Editor)

Overview

Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. - Transcends multiple neural, neurochemical and behavioral domains - Summarizes advances in the field of addiction research since the advent of optogenetics - Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Product Details

ISBN-13:	9780128123317
Publisher:	Elsevier Science & Technology Books
Publication date:	08/24/2018
Sold by:	Barnes & Noble
Format:	eBook
Pages:	306
File size:	32 MB
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About the Author

Mary Torregrossa has conducted research in the neuroscience of addiction field for 16 years, including studying opiates, psychostimulants, alcohol, and cannabinoids in addition to investigating the neural mechanisms underlying addiction and potential treatments using a variety of techniques, including behavioral analyses, pharmacology, microdialysis, biochemistry, molecular biology, and proteomics. Dr. Torregrossa began her career by earning her Ph.D. at the University of Michigan in the laboratory of Dr. James Woods, one of the “founding fathers” of behavioral pharmacological studies of addictive disorders using animal models, and, as a postdoctoral fellow, trained with two other leaders in the addiction field, Dr. Peter Kalivas and Dr. Jane Taylor. Dr. Torregrossa is now an independent investigator in the Department of Psychiatry at the University of Pittsburgh, funded by the National Institute on Drug Abuse. She is the author of nearly 30 peer-reviewed articles in the field, as well as numerous reviews and book chapters.

Table of Contents

1. IntroductionMary M. Torregrossa2. Animal Models of AddictionRita A. Fuchs3. Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug AddictionA.J. Robison4. Neural Circuit Alterations in AddictionMatt Hearing and Eden Marie Anderson5. Glutamatergic Neuroplasticity in AddictionL. A. Knackstedt and Allison Bechard6. Neural Ensemble Encoding of Addictive BehaviorBruce Hope7. Interoceptive Stimulus Effects of Drugs of AbuseJennifer Murray8. Maladaptive Memory Mechanisms in Addiction and RelapseMary M. Torregrossa9. Neural Morphology and AddictionPatrick Mulholland10. Mechanisms regulating compulsive drug behaviorsDavid M. Dietz11. Role of Stress-Associated Signaling in AddictionJohn Mantsch and Elizabeth M. Doncheck12. Negative Reinforcement Mechanisms in AddictionOlivier George13. Circadian Rhythms and AddictionRyan Logan14. Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by StressJacqueline McGinty15. The Role of Norepinephrine in Addiction: Past, Present, and FutureDavid Weinshenker16. Glial Dysregulation in AddictionDavid Baker17. Role of the Extracellular Matrix in AddictionPeter W. Kalivas and Lauren Beloate18. Striatal cell-type specific plasticity in addictionMary Kay Lobo19. Harnessing Circuits for the Treatment of Addictive DisordersChristelle Baunez20. Conclusions and Future DirectionsMary M. Torregrossa

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From the Publisher

A comprehensive guide to the neural, cellular, behavioral and cognitive mechanisms behind addictive disorders