Neurodegenerative Diseases: Unifying Principles
As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.

Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.
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Neurodegenerative Diseases: Unifying Principles
As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.

Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.
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Neurodegenerative Diseases: Unifying Principles

Neurodegenerative Diseases: Unifying Principles

Neurodegenerative Diseases: Unifying Principles

Neurodegenerative Diseases: Unifying Principles

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Overview

As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.

Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

Product Details

ISBN-13: 9780190233563
Publisher: Oxford University Press
Publication date: 11/14/2016
Pages: 360
Product dimensions: 7.20(w) x 10.10(h) x 0.90(d)

About the Author

Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been featured in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards.

Dr. Jagan A Pillai is a cognitive neurologist at the Lou Ruvo Center for Brain Health, Cleveland Clinic. He trained as a medical doctor at the University of Kerala and obtained a PhD from Northwestern University. His training in neurology was completed at the Albert Einstein College of Medicine and at the University of California San Diego. Dr. Pillai is closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases and in developing diagnostic and treatment strategies against neurodegenerative diseases.

Table of Contents

Table of Contents

List of Contributors

1 Neurodegenerative Diseases: Evolving Unifying Principles
Jeffrey Cummings and Jagan Pillai

2 Neurodegenerative Diseases as Protein Misfolding Disorders
Tomohiro Nakamura and Stuart A. Lipton

3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD
Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny

4 Neuroinflammation and Neurodegenerative Diseases
Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb

5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding
Jiri Safar

6 Neuropsychiatric Features Across Neurodegenerative Diseases
Claudia R. Padilla and Mario F. Mendez

7 Brain Circuits: Pathway for NDD
William Seeley

8 Fluid Biomarkers Indicative of Neurodegenerative Diseases
Henrik Zetterberg and Jonathan M. Schott

9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features
Jagan Pillai

10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms
Lynn M. Bekris and James B. Leverenz

11 An Epigenetics Perspective on Diseases of the Central Nervous System
Diego Mastroeni

12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases
Andrew B. Knot and Ella Bossy-Wetzel

13 Cell Culture and iPS Cells and Neurodegenerative Diseases
Roxana Nat and Andreas Eigentler

14 Animal Models of Neurodegenerative Diseases
David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla

15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases
Peng Lei, Scott Ayton, and Ashley I. Bush

16 Disease modifying therapies in neurodegenerative disorders
Janelle Drouin-Ouellet and Roger A. Barker

17 Immunotherapy for Neurodegenerative Disorders
David Morgan

18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles
Jeffrey Cummings and Kate Zhong

19 Conclusions on Neurodegenerative Disorders: Unifying Principles
Jagan Pillai and Jeffrey Cummings

Index
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