Cognitive function involves the participation of many different neurotransmitter systems in a variety of brain areas. The centerpiece of investigation regarding cognitive function has classically been the cholinergic system, but it has beome increasingly clear that other transmitter systems interact with cholinergic systems to provide the neural basis for cognitive function.
This book brings together cutting edge research to determine how the transmitter interactions form the mechanistic bases for attention, learning and memory. This research on transmitter interactions not only provides a more accurate, though complex, picture of how the brain works to provide cognitive function, it also provides important new levels of understanding about the mechanisms of cognitive dysfunction and novel avenues for therapeutic treatment. The researchers who contributed to this volume both reviewed the latest findings but also point to the directions of advancement of the field of neurotransmitter interactions and cognitive function.
Table of Contents1 Interactions among Neurotransmitters: Their Importance to the “Integrated Organism”.- 2 The Cholinergic Basal Forebrain and its Telencephalic Targets: Interrelations and Implications for Cognitive Function.- 3 Synaptic Organization of Basal Forebrain Cholinergic Projection Neurons.- 4 Functional Pharmacology of Basal Forebrain Dopamine.- 5 Cholinergic/Noradrenergic Interactions and Memory.- 6 The Role of the Noradrenergic System in Higher Cerebral FunctionsExperimental Studies About the Effects of Noradrenergic Modulation on Electrophysiology and Behavior.- 7 Septal Noradrenergic and Glutamatergic Influences on Hippocampal Cholinergic Activity in Relation to Spatial Learning and Memory in Mice.- 8 Neurotransmitter Interactions and Responsivity to Cholinomimetic Agents.- 9 The Importance of D1 and D2 Interactions with Nicotinic and Muscarinic Systems for Working Memory Function.- 10 Neurotransmitter Systems in Hippocampus and Prelimbic Cortex, Dopamine-Acetylcholine Interactions in Hippocampus, and Memory in the Rat.- 11 Nicotinic-Muscarinic Interactions in Cognitive Function.- 12 The Influence of Neurotensin upon Cholinergic Function.- 13 Serotonin Influences on Cholinergic Function: Possible Interactions in Learning and Memory.- 14 The Contribution of the Serotonergic Innervation of the Hippocampus to the Effects of Combined Cholinergic/Serotonergic Deficits.- 15 Overlapping Neural Substrates Underlying Defense Reactions, Aversive Memory, and Convulsive Behavior.- 16 Potentiation of the Effects of Antimuscarinic Drugs on Behavior by Serotonin Depletion: Specificity and Relation to Learning and Memory.- 17 Interactions of Neurotransmitters and Neuroanatomy: It’s Not What You Do, It’s the Place that You Do It.- 18 Intraseptal GABAergic Infusions Disrupt Memory in the Rat: Method and Mechanisms.- 19 Working Memory and Cholinergic Autoregulation in the Medial Septal Area.- 20 Modulation of Memory by Benzodiazepine-Acetylcholine Interactions.- 21 Cognition Enhancement Based on GABA-Cholinergic Interactions.- 22 Transmitter Interactions and Cognitive Function: Appreciation of the Concert.