New Rapid-acting Antidepressants

This book discusses new candidates for rapid—acting antidepressants, such as (R)—ketamine, (2R,6R)—hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of n...