Oligonucleotide Synthesis: Methods and Applications

A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the prool highlights are a novel two—step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell—specific targeting, and triple helix formation. The applications include using molecular beacons to moni...