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P-450 and Chemical Carcinogenesis

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This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes· with Particular Emphasis on Cyhrome P-450" which was held in Tokyo on November 21, 1983. The principal role of microsomal cyhrome P-450 in the metabolic activation of various chemical carcinogens in animal cells has been well established. The activated chemical carcinogens induce mutations of the ce...