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PEGylated Protein Drugs: Basic Science and Clinical Applications

By Francesco M. Veronese (Editor)
Hardcover
$219.99
By Francesco M. Veronese (Editor)
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well ...

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