This Symposium was the fourth in a series which began in Milan, Italy, in 1960. Each meeting has introduced or developed some new concepts in the areas of lipid metabolism and drugs. The meetings have served as a springboard for new ideas which have, between meetings, become accepted and exploited. This meeting has been no exception. Principal among the many new concepts discussed were lipoprotein synthesis and metabolism, apoprotein structure and function, whole body metabolism of cholesterol, and aspects of myocardial and aortic metabolism. The Symposium also included a summary of current thought on management of hyperlipemias and atherosclerosis. Data on more than 30 drugs were introduced and discussed. We have every expectation that the next Symposium will include material which is now only in the formative stage. The Organizing Committee would like to acknowledge the invaluable assistance of Miss Mary Constant, Mr. Ralph H. Hollerorth, Mrs. Carolyn P. Hyatt and Miss Jane T. Kolimaga, whose efforts contributed significantly (p < .001) to the success of this Symposium.
Table of ContentsOpening Remarks.- Newer Developments in Lipid Biochemistry.- Synthesis and Secretion of Plasma Lipoproteins.- The Apolipoproteins.- Mechanisms of Hyperlipoproteinemia.- Clearing Factor Lipase and Its Role in the Regulation of Triglyceride Utilization. Studies on the Enzyme in Adipose Tissue.- Hormonal Control of Lipolysis in Adipose Tissue.- The Role of Cyclic 3?5?-AMP and Its Derivatives in Lipid and Carbohydrate Metabolism.- Biochemical Changes in the Artery Wall during Genesis and Regression of Atheromatous Lesions.- Newer Aspects of Drugs Affecting Lipid Metabolism.- Effect of Some Drugs on Free Fatty Acids and Triglycerides in Plasma and Tissues.- Effect of Drugs on Plasma Triglyceride Metabolism.- The Economy of Cholesterol in Man: Drug Effects.- Effect of Drugs on the Metabolism of Bile Acids.- Hypolipidemic Drugs and Lipoprotein Metabolism.- Serum and Tissue Lipid Metabolism and Effect of Nicotinic Acid in Different Types of Hype rlipidemia.- The Combined Use of Clofibrate and Anion Exchange in the Treatment of Hypercholesterolemia.- Can Heart Disease be Postponed or Prevented?.- Atherogenic and Thrombogenic Mosaic.- Risk Factors in Coronary Heart Disease: Possibilities of Prevention in the Federal Republic of West Germany.- Role of Diet in the Primary Prevention of Coronary Heart Disease.- Prospects with Multifactorial Approaches Emphasizing Improvement in Life Style.- Cholesterol-Lowering in Man.- Ischemic Heart Disease: A Secondary Prevention Trial using Clofibrate (Atromid-S).- Closing Session.- Antilipemic Drugs and the Position of the FDA.- Concluding Remarks.- Abstracts of Submitted Papers.- Author Index.