Pulmonary Physiology, Ninth Edition / Edition 9
ISBN-10:
1260019330
ISBN-13:
9781260019339
Pub. Date:
01/08/2018
Publisher:
McGraw-Hill Professional Publishing
Pulmonary Physiology, Ninth Edition / Edition 9

Pulmonary Physiology, Ninth Edition / Edition 9

by Michael G. Levitzky
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Product Details

ISBN-13: 9781260019339
Publisher: McGraw-Hill Professional Publishing
Publication date: 01/08/2018
Edition description: New Edition
Pages: 320
Sales rank: 545,820
Product dimensions: 5.90(w) x 8.90(h) x 0.60(d)

About the Author

Michael G. Levitzky, PhD Professor, Director of Basic Science Curriculum, Louisiana State University School of Medicine, New Orleans.

Table of Contents

Preface vii

Chapter 1 Function and Structure of the Respiratory System 1

Functions of the Respiratory System 1

Structure of the Respiratory System 4

Key Concepts 11

Suggested Readings 11

Chapter 2 Mechanics of Breathing 12

Generation of a Pressure Difference Between Atmosphere and Alveoli 13

Pressure-Volume Relationships in the Respiratory System 21

Interaction of Lung and Chest Wall: The Static Pressure-Volume Curve 31

Airways Resistance 35

The Work of Breathing 53

Key Concepts 55

Clinical Problems 55

Suggested Readings 58

Chapter 3 Alveolar Ventilation 59

The Lung Volumes 59

Measurement of the Lung Volumes 62

Anatomic Dead Space and Alveolar Ventilation 70

Measurement of Alveolar Ventilation 72

Alveolar Ventilation and Alveolar Oxygen and Carbon Dioxide Levels 77

Regional Distribution of Alveolar Ventilation 81

The Closing Volume 85

The Effects of Aging 87

Key Concepts 89

Clinical Problems 89

Suggested Readings 92

Chapter 4 Blood Flow to the Lung 94

The Bronchial Circulation 95

The Functional Anatomy of the Pulmonary Circulation 97

Pulmonary Vascular Resistance 100

The Regional Distribution of Pulmonary Blood Flow: The Zones of the Lung 107

Hypoxic Pulmonary Vasoconstriction 114

Effects of Mechanical Ventilation on Pulmonary Blood Flow 116

Pulmonary Edema 117

Key Concepts 120

Clinical Problems 121

Suggested Readings 122

Chapter 5 Ventilation-Perfusion Relationships 124

The Concept of Matching Ventilation and Perfusion 124

Consequences of High and Low V/Q 125

Testing for Nonuniform Distribution of Inspired Gas and Pulmonary Blood Flow 127

Regional V/Q Differences and Their Consequences in the Lung 136

Key Concepts 139

Clinical Problems 139

Suggested Readings 141

Chapter 6 Diffusion of Gases and Interpretation of Pulmonary Function Tests 142

Fick's Law for Diffusion 143

Limitations of Gas Transfer 145

Diffusion of Oxygen 147

Diffusion of Carbon Dioxide 149

Measurement of Diffusing Capacity 149

Interpretation of Pulmonary Function Tests 152

Key Concepts 154

Clinical Problems 154

Suggested Readings 156

Chapter 7 Transport of Oxygen and Carbon Dioxide in the Blood 157

Transport of Oxygen by the Blood 157

Hemoglobin and the Physiologic Implications of the Oxyhemoglobin Dissociation Curve 160

Influences on the Oxyhemoglobin Dissociation Curve 164

Transport of Carbon Dioxide by the Blood 171

The Carbon Dioxide Dissociation Curve 173

The Bohr and Haldane Effects Explained 174

Key Concepts 176

Clinical Problems 176

Suggested Readings 178

Chapter 8 Acid-Base Balance 179

The Chemistry of Acids, Bases, and Buffers 179

Buffer Systems of the Human Body 182

Acidosis and Alkalosis 188

Respiratory and Renal Compensatory Mechanisms 192

Clinical Interpretation of Blood Gases and Acid-Base Status 194

The Causes of Hypoxia 197

Key Concepts 200

Clinical Problems 201

Suggested Readings 205

Chapter 9 Control of Breathing 206

The Generation of Spontaneous Rhythmicity 207

The Medullary Respiratory Center 209

The Pontine Respiratory Groups 211

Spinal Pathways 211

Reflex Mechanisms of Respiratory Control 212

Influences of Higher Centers 217

The Response to Carbon Dioxide 218

The Response to Hydrogen Ions 226

The Response to Hypoxia 227

The Response to Exercise 227

Key Concepts 231

Clinical Problems 231

Suggested Readings 233

Chapter 10 Nonrespiratory Functions of the Lung 235

Pulmonary Defense Mechanisms 235

Nonrespiratory Functions of the Pulmonary Circulation 242

Metabolic Functions of the Lung 244

Key Concepts 247

Suggested Readings 249

Chapter 11 The Respiratory System Under Stress 250

Exercise and the Respiratory System 250

Altitude and Acclimatization 257

Diving and the Respiratory System 264

Sleep and the Respiratory System 271

Key Concepts 273

Clinical Problems 273

Suggested Readings 278

Clinical Problem Answers 281

Appendix 294

I Symbols used in Respiratory Physiology 294

II The Laws Governing the Behavior of Gases 294

III Frequently used Equations 295

IV Table of Normal Respiratory and Circulatory Values 296

Index 297

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