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Recombinant DNA Technologies in Neuroendocrinology

By Hiroo Imura (Editor), Y. Dong (Contribution by), A. Fukamizu (Contribution by), R.H. Goodman (Contribution by), J.-A. Gustafsson (Contribution by), V. Höllt (Contribution by), M.G. Kaplitt (Contribution by), L.A. Kukstas (Contribution by), P.-M. Lledo (Contribution by), M.J. Low (Contribution by), K. Murakami (Contribution by), Y. Nakai (Contribution by), S. Okret (Contribution by), D.W. Pfaff (Contribution by), S.D. Rabkin (Contribution by), R. Rehfuss (Contribution by), D. Richter (Contribution by), T. Tsukada (Contribution by), J.-D. Vincent (Contribution by), K. Walton (Contribution by)
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By Hiroo Imura (Editor), Y. Dong (Contribution by), A. Fukamizu (Contribution by), R.H. Goodman (Contribution by), J.-A. Gustafsson (Contribution by), V. Höllt (Contribution by), M.G. Kaplitt (Contribution by), L.A. Kukstas (Contribution by), P.-M. Lledo (Contribution by), M.J. Low (Contribution by), K. Murakami (Contribution by), Y. Nakai (Contribution by), S. Okret (Contribution by), D.W. Pfaff (Contribution by), S.D. Rabkin (Contribution by), R. Rehfuss (Contribution by), D. Richter (Contribution by), T. Tsukada (Contribution by), J.-D. Vincent (Contribution by), K. Walton (Contribution by)
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1.1 Mechanism of Action of Glucocorticoid Hormones The current model of glucocorticoid hormone action is summarized in Fig. 1. After synthesis, glucocorticoids are secreted into the blood stream and trans- ported to target cells where they bind with high affinity (K-1O-9M) and d specificity to the intracellular glucocorticoid receptor (GR) protein. The sub- cellular localization of hormone-free GR is still a controversial issue. However, most data support the idea that unliganded GR is in t...

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