Role of Oxidative Stress in Disease Initiation and Progression

Oxidative stress plays a pivotal role in the onset and progression of a wide spectrum of human diseases by disrupting redox homeostasis and promoting cellular and molecular damage. Excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), coupled with inadequate antioxidant defenses, leads to structural and functional alterations in key organs, including the brain, bone, kidney, and liver. In this book, the molecular mechanisms by which OS affects hepatic pa...