Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases

This book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mihondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mihondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mihondrial DNA, are presented. The following chapter demonstrates ...