Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

by Earl Prohofsky
ISBN-10:
052167557X
ISBN-13:
9780521675574
Pub. Date:
07/31/2005
Publisher:
Cambridge University Press
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Overview

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.

Product Details

ISBN-13: 9780521675574
Publisher: Cambridge University Press
Publication date: 07/31/2005
Pages: 240
Product dimensions: 5.98(w) x 8.98(h) x 0.51(d)

Table of Contents

Preface; 1. Introduction; 2. Macromolecular stability; 3. Lattice dynamics; 4. Effective phonon theory; 5. Premelting disrupted chemical bonds; 6. Co-operative melting; 7. Strained chemical bonds: salt and pressure effects; 8. Bond disruption and conformation change: B to Z confirmation change in DNA; 9. Hydration effects: structural water; 10. Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA bonding constant; 11. Non repeating DNA; 12. Cutting and splicing: junctions, inserts and the replicating fork; 13. Interaction between a helix and a single attached molecule; 14. Energy considerations in bond opening; Appendix 1; Appendix 2; Appendix 3. Index

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