Targeting the STAT Pathway in Cancer

The JAK-STAT signal pathway refers to a cytokine-stimulated signal transduction pathway which plays an important role in numerous biological processes which include cell proliferation, differentiation, apoptosis and immune regulation. The signal transducer and activator of transcription (STAT) pathway is linked upstream with the Janus kinase (JAK) family of proteins. It is also capable of integrating inputs from several signaling pathways. Each member of the family performs a distinct role ...