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The Extracellular Matrix in Genetic Skeletal Disorders
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This book explores how defects in extracellular matrix (ECM) proteins, their post-translational modifications, and intracellular trafficking impact cartilage and bone integrity. It underscores the ECM's role in providing structural support, establishing morphogenetic gradients, and interacting with cell surface receptors in musculoskeletal tissues.
The book delves into the structure and biology of the ECM in the skeleton, discussing skeletal disorders caused by mutations in genes associated ...