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The Role of ThPOK in Control of CD4/CD8 Lineage Commitment
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During αβ T cell development, cells diverge into alternate CD4 helper and CD8+ cytotoxic T cell lineages. The precise correlation between a T cell's CD8 and CD4 choice and its TCR specificity to class I or class II MHC was noted more than 20 years ago, and establishing the underlying mechanism has remained a focus of intense study since then. This review deals with three formerly discrete topics that are gradually becoming interconnected: the role of TCR signaling in lineage commitment, the...
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