Trends in Drug Research II

Trends in Drug Research II

by H. van der Goot

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Product Details

ISBN-13: 9780080543246
Publisher: Elsevier Science
Publication date: 01/16/1998
Series: Pharmacochemistry Library , #29
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 246
File size: 9 MB

Table of Contents

Insights into the structure and function of genetic disease genes from genome research and clues for drug therapy (P.L. Pearson). New Developments in synthetic medicinal chemistry (F. Gaultieri). New biocatalytic approaches for the synthesis of chiral drugs, intermediates, and substrates (K. Laumen et al.). Ligands for the 5-HT 2C receptor as potential antidepressents and anxiolytics (D. Leysen, J. Kelder). 5-HT 1A-affinity, activity and selectivity versus D2-receptors of flesinoxan and analogous (W. Kuipers). Pharmacokinetics and metabolism in drug development: current and future strategies (D.D. Breimer). Novel approaches towards anti-HIV chemotherapy (E. De Clercq). HBY 097 - a second-generation nonnucleoside inhibitor of the HIV-1 reverse transcriptase (J-P. Kleim). The HIV tat-TAR interaction, a novel target for drug discovery (J. Karn et al.). Diverse approaches to combinatorial library design (E.J. Martin et al.). Heterocyclic mixture- based combinatorial libraries: synthesis and analysis of composition (J.S. Kiely, Y. Pei). Chemistry and SAR of prokinetic motilides: non peptidic motilin receptor agonists (P.A. Lartey). Modulators of 5-HT functions in the treatment of gastrointestinal disorders (F.D. King et al.). The impact of robotics and novel assay technologies on lead discovery processes (J.G. Houston). Hot topics (P. Angeli). Inverse agonism at G protein-coupled receptors. Studies with wild type and mutated adrenergic and opioid receptors (G. Milligan). Antibiotic resistance - a view from the pharmaceutical industry (R. Bax).

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