Biophysics of the Pancreatic ?-Cell

Pancreatic a-cell biophysics has undergone a veritable information explosion in the past two years. Single channel and macroscopic currents have become easily accessible following the introduction of the patch clamp technique. In addition to this new approach, further development of techniques for optical measurements, ion-sensitive microelectrodes, permeabilized cells and mathematical modelling have recently added to the now classical techniques of membrane potential recording and tracer f...