Chromatin Accessibility: Methods and Protocols

This detailed volume provides a comprehensive resource covering the existing and state—of—the—art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk—cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single—molecule and enzymatic approaches to solving the problem of ...