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Product Details

ISBN-13: 9781621820093
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 09/30/2015
Pages: 549
Product dimensions: 7.00(w) x 9.80(h) x 1.20(d)

Table of Contents

Preface

PART 1: MECHANISMS OF RECOMBINATION
An Overview of the Molecular Mechanisms of Recombinational DNA Repair
Stephen C. Kowalczykowski
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
Anuja Mehta and James E. Haber
End Resection at Double-Strand Breaks: Mechanism and Regulation
Lorraine S. Symington
DNA-Pairing and Annealing Processes in Homologous Recombination and Homology-Directed Repair
Scott W. Morrical
Mediators of Homologous DNA Pairing
Alex Zelensky, Roland Kanaar, and Claire Wyman
Regulation of DNA Pairing in Homologous Recombination
James M. Daley, William A. Gaines, YoungHo Kwon, and Patrick Sung
The Dissolution of Double Holliday Junctions
Anna H. Bizard and Ian D. Hickson
Holliday Junction Resolvases
Haley D.M. Wyatt and Stephen C. West
Structural Studies of DNA End Detection and Resection in Homologous Recombination
Christian Bernd Schiller, Florian Ulrich Seifert, Christian Linke-Winnebeck, and Karl-Peter Hopfner

PART 2: REGULATION OF RECOMBINATION AND GENOMIC MAINTENANCE
Regulation of Recombination and Genomic Maintenance
Wolf-Dietrich Heyer
Cell Biology of Mitotic Recombination
Michael Lisby and Rodney Rothstein
Transcription and Recombination: When RNA Meets DNA
Andrés Aguilera and Hélène Gaillard
Recombination and Replication
Aisha H. Syeda, Michelle Hawkins, and Peter McGlynn
Mismatch Repair during Homologous and Homeologous Recombination
Maria Spies and Richard Fishel
The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres
Ylli Doksani and Titia de Lange
Mechanisms of Gene Duplication and Amplification
Andrew B. Reams and John R. Roth
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Rohit Prakash, Yu Zhang, Weiran Feng, and Maria Jasin

PART 3: MEIOTIC RECOMBINATION
Meiotic Recombination: The Essence of Heredity
Neil Hunter
Recombination, Pairing, and Synapsis of Homologs during Meiosis
Denise Zickler and Nancy Kleckner
Mechanism and Regulation of Meiotic Recombination Initiation
Isabel Lam and Scott Keeney
Initiation of Meiotic Homologous Recombination: Flexibility, Impact of Histone Modifications, and Chromatin Remodeling
Lóránt Székvölgyi, Kunihiro Ohta, and Alain Nicolas
DNA Strand Exchange and RecA Homologs in Meiosis
M. Scott Brown and Douglas K. Bishop
The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase
Vijayalakshmi V. Subramanian and Andreas Hochwagen
Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births
Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, and Lisa Lister

Index

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