Electron Microscopy at Molecular Dimensions: State of the Art and Strategies for the Future

If, ten years ago, one had been asked to comment on the prospects of peering into the fmest details of biomolecular organization, most electron microscopists would, I suppose at least, have been quite en­ thusiastic. When, during the early seventies, several groups were success­ ful in visualizing single heavy atoms, which undoubtedly was a techni­ cal triumph, this prompted the most sanguine expectations among bi­ ologists. In the following years, however, it began to transpire that radiat...