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This volume stems from the eighth international symposium and workshop entitled "Hematopoietic Stem Cells VIII" held hosted by the University of Tuebingen, Germany in the fall of 2011. The meeting was designed to bring ~30 leading scientists together to discuss the state-of-the-art in the field of hematopoietic stem cells. Topics reviewed in this volume include: differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches; hematopoietic stem cell expansion; TI...