Mental health and HIV/AIDS are closely interlinked. Mentaldisorders, including substance-use disorders, are associated withincreased risk of HIV infection and affect adherence to andefficacy of antiretroviral treatments. Conversely, HIVinfection can increase risk for neuropsychiatric complicationsincluding stress, mood, and neurocognitive disorders. This book provides clinicians with a comprehensive evidenced-basedand practical approach to the management of patients with HIVinfection and co-morbid mental disorders. It provides up-to-dateand clear overviews of current clinical issues, as well as therelevant basic science. Information and data from studies ofdifferent HIV groups (eg men who have sex with men) make the textrelevant to a broad spectrum of clinicians, including those workingwith low socioeconomic status groups in high income countries andthose working in the developing world.The book uses the popular format of the World PsychiatricAssociation’s Evidence and Experience series. Reviewchapters summarize the evidence on the epidemiology, pathogenesisand clinical aspects of mental disorders in HIV,and interventions(both psychotherapy and psychopharmacology including drug-druginteractions). These are complemented by commentariesaddressing particular facets of each topic and providing insightgained from clinical experience. Psychiatrists, psychologists and all mental health staff workingwith HIV-infected patients will find this book of greatbenefit.
|Series:||WPA Series in Evidence & Experience in Psychiatry Series|
|Product dimensions:||6.70(w) x 9.60(h) x 0.80(d)|
About the Author
John A. Joska is a Head of the Division of Neuropsychiatryin the Department of Psychiatry and Mental Health at the Universityof Cape Town. He is the Director of the UCT HIV Mental HealthResearch Unit, and the Western Cape Provincial Programme Managerfor HIV Psychiatry. His interests are in HIV and Mental Health,particularly mechanisms of HIV-associated neurocognitive disorders,mental health services, and general neuropsychiatry. John completedboth under- and post-graduate training at UCT. Following completionof his fellowship in psychiatry in 2002, he obtained the Mmed(psychiatry) in 2006, and his PhD in the Neurocognitive Disordersof HIV in 2011. John has been involved in several innovativeresearch projects, including the development of assertive communityoutreach programmes in the Province, and the development of asmartphone application to assist primary health care providers toassess for the presence of dementia. His group was recently fundedto conduct a randomized controlled trial of lithium inHIV-associated dementia. He is excited by the opportunities andchallenges provided by working in Cape Town, South Africa.Dan J Stein is Professor and Chair of the Dept of Psychiatryand Mental Health at the University of Cape Town, Director of theMedical Research Council (MRC) Unit on Anxiety Disorders, andVisiting Professor of Psychiatry at Mt. Sinai Medical Schoolin New York. He is interested in the psychobiology andmanagement of the anxiety, obsessive-compulsive and related, andtraumatic and stress disorders. He has also mentored work inother areas that are of particular relevance to South Africa andAfrica, including neuroHIV/AIDS and substance use disorders.Dan did his undergraduate and medical degrees at the University ofCape Town, and his doctorate (in the area of clinical neuroscience)at the University of Stellenbosch. He trained in psychiatry,and completed a post-doctoral fellowship (in the area ofpsychopharmacology) at Columbia University in New York. Histraining also includes a doctorate in philosophy. He isinspired by the way in which psychiatry integrates science andhumanism, and contributes to addressing some of the big questionsposed by life.Dan's work ranges from basic neuroscience, through clinicalinvestigations and trials, and on to epidemiological andcross-cultural studies. He is enthusiastic about thepossibility of clinical practice and scientific research thatintegrates theoretical concepts and empirical data across thesedifferent levels. Having worked for many years in SouthAfrica, he is also enthusiastic about establishing integrativeapproaches to services, training, and research in the context of alow and-middle-income country.
Table of Contents
List of Contributors ixPreface xv1 Epidemiology of Psychopathology in HIV 1Milton L. Wainberg, Karen McKinnon, and FrancineCournosCommentaries1.1 Epidemiology of Psychopathology in HIV: NeurocognitiveDisorders 34Bryan Smith and Ned Sacktor1.2 Depression and Anxiety Disorders in HIV/AIDS 40Seggane Musisi1.3 Substance Use Disorders and HIV: Evolving Syndemics 46Sheri L. Towe and Christina S. Meade1.4 Severe Mental Illness and HIV 55Etheldreda Nakimuli-Mpungu2 Pathogenesis of Mental Health Disorders in HIV 61Gursharan Chana, Chad A. Bousman, and Ian P. EverallCommentaries2.1 Behavioural and Social Risk Factors for HIV 82Landon Myer2.2 Brain Imaging and Neuro-HIV 87Christine Fennema-Notestine2.3 Host Genetics in HIV-Associated Neurocognitive Disorders93Avindra Nath and Wenxue Li2.4 Traumatic Stressors and the Psychoneuroimmunology of HIV/AIDS99Dan J. Stein, John A. Joska, and Kathleen J. Sikkema3 Clinical Aspects of HIV-Related Neurocognitive Disorders107Nicholas W.S. Davies and Bruce J. BrewCommentaries3.1 Clinical Aspects of HIV-Related Neurocognitive Disorders131Robert Paul and Jodi Heaps3.2 Differential Diagnosis in HIV-Associated NeurocognitiveDisorders 137Gabriele Arendt3.3 Psychiatric Disorders and HIV 143Glenn Treisman3.4 Optimizing the Effectiveness of HIV Treatment as Preventionwith Stimulant Users 149Adam W. Carrico4 Treatment of Psychiatric Disorders in HIV 157Maria Ferrara, Ignacio P. Valero, David J. Moore, Adam F.Knight, Nichole A. Duarte, and J. Hampton AtkinsonCommentaries4.1 Combination Anti-Retroviral Treatment and NeuroHIV 194Charles Venuto and Giovanni Schifitto4.2 Psychopharmacology and Psychiatric Co-morbidity 199Mark Halman4.3 Intervention in HIV and Psychiatry: Behavioural andPsychotherapeutic Approaches 205Reuben N. Robbins and Robert H. Remien5 Special Populations and Public Health Aspects 211Francine Cournos, Karen McKinnon, Veronica Pinho, and MiltonWainbergCommentaries5.1 Mental Health Services for HIV in Resource-Limited Settings235Crick Lund5.2 Specifying the Mental Health Context for the Development of HIVPrevention and Treatment Interventions for Men Who Have Sex withMen 240Jessica F. Magidson and Conall O’Cleirigh5.3 Following the Special Populations Home: Children and Families245Lucie Cluver, Mark Boyes, Mark Orkin, Lorraine Sherr, and MalegaKganakga5.4 Gender Issues and the Burden of Disease in Women 256Catherine Mathews and Naeemah AbrahamsIndex 263