This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.
Table of Contents1. Landmarks in the Unnatural History of SCID-hu Mice.- 2. Detection of Human Hematopoietic Stem Cells in SCID-hu Mice.- 3. Human T-Cell Development in SCID-hu Mice.- 4. Effects of Cytokine Administration on Human Hematopoiesis in SCID-hu Mice.- 5. Human Humoral Immunity in SCID Mice.- 6. Antigen-Specific Immune Responses in Human/Mouse Chimeras.- 7. The Hematopathology of HIV-1 Disease: Experimental Analysis In Vivo.- 8. SCID-hu Miceas a Model for the Study of Human Malignancies.- 9. SCID Mice as a Model for Human Leukemias.- 10. Human Hematopoiesis in SCID Mice.