Quincy Harker is back in Charlotte, but things are bad at home. It seems a rogue government agency has kidnapped Uncle Luke and is holding him at an undisclosed location in order to experiment on him, along iwth dozens of other cryptids and supernaturals creatures.
Because kidnapping Count Dracule seemed like a good idea.
Now Harker and his crew have to hunt down a government agency that doesn't exist to rescue Luke from their clutches, while not getting kidnapped themselves. Oh, and there was a jailbreak at Cryptid Gitmo, so now Harker has to hunt down a medusa who's turning douchebros to stone in downtown Charlotte.
Oh, and somebody kinda summoned an Old One at Freedom Park. Then there's the Nazi-punching. It's not a great day for our hero, but it's a worse one for whoever gets in his way.