Researched and written by a group of highly respected professionals in the fields of biochemistry, microbiology, and molecular genetics, this invaluable resource offers a comprehensive treatment on the role of metal ions in regulating genes. In addition to looking at the toxicity effects of metal, this text explores the role of metal ions normal metabolisms, examining both prokaryotes and eukaryotes.
Table of ContentsOverview of cellular inorganic metabolism and the need for gene regulation-- Simon Silver and William Walden; Part I: Bacterial Metal Metabolism. Control of Bacterial Iron Transport by Regulatory Proteins- Klaus Hantke and Volkmar Braun; Metal Cation Regulation in Gram-Positive Bacteria- John D. Helmann; Two-Component Systems in the Regulation of Heavy Metal Resistance- Dietrich H. Nies and Nigel L. Brown; Phosphate Signaling and the Control of Gene Expression in Escherichia coli- Barry L. Wanner; Part II: Animal Metal Metabolism. Translational Regulation of Bioiron- Elizabeth C. Theil; The Iron Responsive Element (IRE), the Iron Regulatory Protein (IRP), and Cytosolic Aconitase: Posttranscriptional Regulation of Mammalian Iron Metabolism- Richard S. Eisenstein, M. Claire Kennedy, and Helmut Beinert; Mechanisms for Induction and Rerepression of Ferritin Synthesis- David P. Mascotti, Lisa S. Goessling, Diane Rup, and Robert E. Thach; Metallothionein Gene Regulation in Mouse Cells- Simon Labbe, Carl Simard, and Carl Seguin; Menkes' and Wilson's Diseases: Genetic Disorders of Copper Transport- Julian F.B. Mercer and James Camakaris. Part III: Lower Eukaryotes and Plants. Metal Ion Stress in Yeast- Dennis R. Winge, Andrew K. Sewell, Wei Yu, Joanne L. Thorvaldsen, and Rohan Farrell; Yeast Metallothionein Gene Regulation- Simon A.B. Knight, Keith A. Koch, and Dennis J. Thiele; The Molecular Biology of Iron and Zinc Uptake in Saccharomyces cerevisiae- David Eide; Metallothionein Gene Regulation in Cyanobacteria- Nigel J. Robinson, Amanda J. Bird, and Jennifer S. Turner; Metallothionein-like Genes and Phytochelatins in Higher Plants- Anthony P. Fordham-Skelton, Nigel J. Robinson, and Peter B. Goldsbrough; Regulation of Ferritin Synthesis and Degradation in Plants- Jean-Francois Briat and Stephane Lobreaux; Reciprocal, Copper-Responsive Accumulation of Plastocyanin and Cytochrome C6 in Algae and Cyanobacteria: A Model for Metalloregulation of Metalloprotein Synthesis- Sabeeha Merchant. Index.