The external signals that control cellular behavior are chanelled through cell surface receptors, that in turn regulate cytoplasmic signaling pathways. Work over the last ten years has indicated that the activation of these intra- cellular signaling pathways depends on a series of protein-protein and protein-phospholipid interactions mediated by modular polypeptide domains. Through their association with specific peptide motifs, these protein modules define a recognition code through which many aspects of cellular function are controlled. The articles in this book describe the varied features of these domains, and outline the structural, biochemical and genetic evidence that demonstrates their importance in co-ordinating cellular responses to external cues.
Table of ContentsList of Contents.- Functions of SH2 and SH3 Domains.- Function of PTB Domains.- Pleckstrin Homology Domains.- Structure and Function of LIM Domains.- WW (WWP) Domains: From Structure to Function.- Modular Domains of Focal Adhesion-Associated Proteins.- Physiological Function of Receptor-SH2 Interactions.- The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action.- PDZ Domains and the Formation of Protein Networks at the Plasma Membrane.- Mechanism and Function of Signaling by the TGFß Superfamily.- Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions.- Signaling Through Grb2/Ash-Control of the Ras Pathway and Cytoskeleton.- Genetic Analysis of Sevenless Tyrosine Kinase Signaling in Drosophila.