Proteoglycans in Stem Cells: From Development to Cancer

This book provides a state—of—the—art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology.
Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self—renewal, senescence and/or differentiation of stem cells du...