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Schizophrenia remains an enigma to many clinicians, despite recent progress in the scientific understanding of its causes, symptoms and potential treatments. Whilst the DSM-IV and ICD-10 classification systems have provided a reasonably reliable set of diagnostic criteria for 'schizophrenia', the validity of the construct remains elusive, and clinicians and researchers need to be wary about accepting these as definitive. Indeed schizophrenia remains a clinical diagnosis, based on certain si...