Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine ...