Still Down: What to Do When Antidepressants Fail

Expert insight and advice to help people with treatment-resistant depression feel better.

Major depressive disorder is a common medical condition that can be disabling and can persist for months, even years. Many people experience depression symptoms that resist treatment. Although they try various combinations of medications, psychotherapy, or electroconvulsive therapy, their symptoms don’t improve. What can people who have treatment-resistant depression do to overcome their depression and ...