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SUMO Protocols

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Post—translational protein modifications by members of the ubiquitin family are widely recognized as important regulatory control systems for a variety of biological pathways. Their influence on eukaryotic cellular metabolism is comparable to that of other modifi— tions such as phosphorylation, acetylation and methylation. The small ubiquitin—related modifier SUMO uses a conjugation and de—conjugation system closely related to that of ubiquitin itself; yet, the functions of the SUMO system ...