Pub. Date:
Springer US
The Sodium-Hydrogen Exchanger: From Molecule to its Role in Disease / Edition 1

The Sodium-Hydrogen Exchanger: From Molecule to its Role in Disease / Edition 1


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Product Details

ISBN-13: 9781402074745
Publisher: Springer US
Publication date: 06/30/2003
Edition description: 2003
Pages: 317
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1: Regulation of Intracellular pH in Mammalian Cells. 1. Introduction. 2. Intracellular Compartmentalization Of pH. 3. Cytoplasmic pH. 4. Intracellular Buffers. 5. Measurement Of pHi During Acid-Base Loading. 6. Transport Systems That Regulate pHi. 2: Molecular and Functional Diversity of Mammalian Na+/H+ Exchangers. 1. Introduction. 2. Genetic Heterogeneity. 3. Conclusion.3: Two Functional Regulatory Factors of Na+/H+ Exchangers: The Proton and aHP. 1. Introduction. 2. The Proton. 3. CHP. 4. Conclusion.4: Regulation of Expression of the Na+/H+ Exchanger in the Myocardium and Other Tissues. 1. Introduction. 2. Na+/H+ Exchanger Expression Varies In Response To The Environment. 3. Transcriptional Regulation Of The Na+/H+ Exchanger Gene. 4. Conclusion. 5: Na-H Exchange Function in Colonic Epithelial Cells. 1. Introduction. 2. Apical Membrane NHEs. 3. Basolateral Membrane NHEs. 6: NhaA Na+/H+Antiporter. Structure, Mechanism and Function in Homestasis of Na+ and pH. 1. Introduction. 2. The Response to Na+ Occurs At The Transcription Level. 3. The Ecological Importance Of The Antiporters In The Enteric Bacteria Escherichia coli And Vibrio cholerae. 4. The NhaA Protein. 5. Relationship Between Function And Structure Of NhaA. 6. Dynamics Of NhaA. 7. Dynamics In 3D Of The pH Induced Conformational Changes Of NhaA. 8. Conclusion. 7: The Use of Transgenic Animal Models to Study Na+/H+ Exchange. 1. Introduction. 2. Transgenic Studies On The NHE1 Isoform Of The Na+/H+ Exchanger. 3. Transgenic Studies On The NHE2 And NHE3 Isoform Of Na+/H+ Exchanger. 4. Pitfalls In Transgenic Studies. 5. Conclusion. 8: pH-Regulatory Mechanisms in the Mammalian Oocyte and Early Embryo. 1. Introduction. 2. Oocyte And Embryo Development. 3. Expression Of Na+/H+ Exchanger (NHE) And Anion Exchanger (AE) Isoforms In Mammalian PI Embryos. 4. Activity Of pHi-Regulatory Mechanism In PI Embryos. 5. pHiRegulatory Mechanisms During Meiosis And Fertilization. 6. Conclusion. 9: Na+/H+ Exchanger Activation by Myocardial Stretch. 1. Introduction. 2. Mechanism Of Stretch-Induced Increase Of The NHE Activity. 3. Mechanical Counterpart Of Stretch-Induced Increase Of The NHE Activity. 10: The Paradoxical Role of Na+/H+ Exchanger in the Diabetic Heart. 1. Introduction. 2. Depressed Na+/H+ Exchanger (NHE) Activity In Insulin-Deficient (TYPE I) Diabetes And Associated Increased Resistance Of Diabetic Hearts To Ischemia And Reperfusion Injury. 3. NHE In Non-Insulin-Dependent (TYPE 2) Diabetes. 4. Conclusion. 11: Role of Na-H Exchanger in Vascular Remodelling in Diabetes. 1. Introduction. 2. Mechanism And Processes Controlling The Activity Of NHE-1. 3. Cellular Physiology Of The Activation Of NHE. 4. Ion Transport And Cytoskeleton In The Cellular Function Of NHE1. 12: The Potential Role of the Na+/H+ Exchanger in Ischemia/Reperfusion Injury of the Central Nervous System. 1. Introduction. 2. Na+/H+ Exchange, Stroke And Potential Adverse Consequences. 3. Conclusion. 13: Receptor-Mediated Regulation of the Cardiac Sarcolemmal Na+/H+ Exchanger. 1. Introduction. 2. Regulation Of Cardiac Sarcolemmal NHE Activity By Receptor Activation. 3. Physiological Importance Of Receptor-Mediated Regulation Of The Sarcolemmal NHE. 4. Pathophysiological Importance Of Receptor-Mediated Regulation Of The Sarcolemmal NHE. 5. Conclusion. 14: Role of NHE-1 in Cardiac Hypertrophy and Heart Failure. 1. Introduction. 2. Rationale For NHE-1 Involvement In Cardiac Hypertrophy And Heart Failure. 3. Experimental Evidence For NHE-1 Involvement In Hypertrophy And Heart Failure. 4. Potential Mechanisms For NHE-1 Involvement In Hypertrophy And Heart Failure. 5. Conclusion. 15: Mechanisms Underlying NHE-1 Involvement in Myocardial Ischemic and Reperfusion Injury. 1. Introduction. 2. Cellular Localization Of NHE-1 In The Heart. 3. Regulation Of NHE-1 Activity In The Cardiac Cell. 4. Mechanisms Underlying NHE Involvement In Myocardial Ischemic And Reperfusion Injury. 5. Potent Antiarrhythmic Effect Of NHE-1 Inhibition. 6. Other Potential Mechanims Mediating Cardioprotective Effects Of NHE-1 Inhibitors. 7. Conclusion. 16: Chemistry of NHE Inhibitors. 1. Introduction. 2. Chemical Classes Of NHE Inhibitors. 17: Development of NHE Inhibitors for Cardiovascular Therapeutics. 1. Introduction. 2. Clinical Trials Performed With NHE-1 Inhibitors In Patients Exposed To Myocardial Ischemia/Reperfusion. 3. Apparent Contradiction Between Preclinical Data Of NHE-1 Inhibitors And The Outcome Of Clinical Trials. 4. Preclinical Evidence For A Central Role Of NHE-1 In Post MI Remodeling And Heart Failure. 5. Conclusions And Future Directions. 18: Cardiac Protection by NHE Inhibitors. 1. Introduction. 2. NHE-1 Inhibition And Cardioprotection. 3. Clinical Trials With NHE-1 Inhibitiors: Infarct Size Reduction. 19: NHE-1 Inhibitors: Potential Application in Cardiac Surgery. 1. Introduction. 2. Myocardial Dysfunction After Cardiac Surgery. 3. Cardioprotective Effects Of NHE-1 Inhibition. 4. Myocardial Protection For Transplantation. 5. Potential For NHE-1 Activation During Cardiac Surgery. 6. Clinical Studies Of NHE-1 Inhibition In Cardiac Surgery. 7. Conclusion. 20: NHE-1 Inhibition: A Potential New Treatment for Resuscitation from Cardiac Arrest. 1. Introduction. 2. Potential Role Of NHE-1 During Cardiac Arrest. 3. Myocardial Effects Of Ventricular Fibrillation. 4. NHE-1 Inhibitors. 5. Myocardial Abnormalities During VF And Effects Of NHE-1 Inhibition. 6. Clinical Implications.

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