Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights

Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights

by Teresa Carlomagno (Editor)

Paperback(2009)

$399.99
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Product Details

ISBN-13: 9783642435942
Publisher: Springer Berlin Heidelberg
Publication date: 11/05/2014
Series: Topics in Current Chemistry , #286
Edition description: 2009
Pages: 331
Product dimensions: 6.10(w) x 9.25(h) x (d)

Table of Contents

Macrolide-Based Microtubule-Stabilizing Agents – Chemistry and Structure–Activity Relationships.- The Chemical Synthesis of Discodermolide.- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR.- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.

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