Depression: Biology, Psychodynamics, and Treatment

I have of late-but wherefore I know not-lost all my mirth, foregone all custom of exercises, and indeed it goes so heavily with my disposition that this goodly frame, the earth, seems to me a sterile promontory .... Hamlet, in Hamlet, Act II, Sc. 2. The numbers may have been fewer in Shakespeare's time, but the symp­ toms were the same. Now, each year, millions instead of thousands of people suffer from a clinical depression severe enough for them to seek help from medical and mental health...