The Role of Nitric Oxide in Heart Failure

Nitric oxide (NO) is one of the most remarkable biological molecules characterized at the turn of XX century. Small in size, but ubiquitous and complex in its network of molecular, cellular and organ inter- tions, NO plays an important role in mammalian and non-mammalian biology. The scope and versatility of NO actions on the biological systems range from neuromodulation and regulation of cardiovascular homeostasis to cell signaling and immunity. An impressive array of physiologic and patho...