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Three prominent world figureheads disappear following The World Summit in Kuala Lumpur. The following day, U.S. President John Remy is found dead in his hotel room.

Meanwhile, two friends on a road trip across North America come to the aid of a mysterious woman, washed up on the banks of the Colorado River. Somehow, all these events are linked.

Choosing to help her plunges them into a nightmarish race across the globe, for she holds a secret that defies all we know about human evolution. Pu...