Genome Sequencing Technology and Algorithms

by Sun Kim, Haixu Tang, Elaine Mardis

Overview

The 2003 completion of the Human Genome Project was just one step in the evolution of DNA sequencing. Now from a "who's who" of pioneers in the field comes the latest genome sequencing and assembly advances that are redefining the field. This trail-blazing work gives researchers unparalleled access to state-of-the-art DNA sequencing technologies, new algorithmic sequence assembly techniques, and emerging methods for both resequencing and genome analysis that together form the most solid foundation possible for tackling experimental and computational challenges in the genome sciences today.

Product Details

ISBN-13:	9781596930940
Publisher:	Artech House, Incorporated
Publication date:	10/31/2007
Edition description:	New Edition
Pages:	259
Product dimensions:	6.20(w) x 9.20(h) x 0.80(d)

Table of Contents

New DNA Sequencing Technology — An overview. Massively parallel sequencing by synthesis-pyrosequencing. Massively parallel sequencing by synthesis-other approaches. Polymerase colonies ("polonies"). Nanopore sequencing. Sequencing within a zero-mode waveguide. DNA Fragment Assembly — An overview. Arachne. EULER. CAP. Phred/Phrap/Consed. AMASS. TIGRassembler and Scaffolder. Celera Assembler. Comparative Sequencing — An overview. Single nucleotide polymorphism (SNP). Genome rearrangement. Opigenomics. Comparative sequencing and assembly.